December in South San Francisco is the coldest month of the year. In December, the weather in South San Francisco is typically warm. Average daily high temperature in December is about 13 degrees above zero. On average, South San Francisco has 14 sunny, 12 partly cloudy, and 5 rainy days in December. The rains are usually light. December as well as January, February, and March is considered the most uncomfortable time to visit South San Francisco.