October in Carlisle is the cloudiest month of the year. In October, the weather in Carlisle is typically warm. Average daily high temperature in October is about 12 degrees above zero. On average, Carlisle has 17 rainy, 7 partly cloudy, 6 cloudy, and 1 sunny day in October. The rains are usually heavy. October as well as January, February, March, and April is considered the most uncomfortable time to visit Carlisle.