April in Des Moines is the rainiest month of the year. In April, the weather in Des Moines is typically warm. Average daily high temperature in April is about 14 degrees above zero. On average, Des Moines has 13 rainy, 9 partly cloudy, 7 sunny, and 1 cloudy day in April. The rains are usually heavy. April as well as February, March, November, and December is considered the most uncomfortable time to visit Des Moines.